Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice
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چکیده
منابع مشابه
Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.
10.1152/ japplphysiol.00832.2001.-To examine the effects of gene inactivation on the plasticity of skeletal muscle, mice null for a specific myosin heavy chain (MHC) isoform were subjected to a voluntary wheel-running paradigm. Despite reduced running performance compared with nontransgenic C57BL/6 mice (NTG), both MHC IIb and MHC IId/x null animals exhibited increased muscle fiber size and mus...
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Sepsis induces an acute inflammatory response in the liver, which can lead to organ failure and death. Given the anti-inflammatory effects of exercise, we hypothesized that habitual physical activity could protect against acute sepsis-induced liver inflammation via mechanisms, including heat shock protein (HSP) 70/72. Male C57BL/6J mice (n = 80, ∼8 wk of age) engaged in physical activity via vo...
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A 01 VOLUNTARY WHEEL RUNNING CAN IMPROVE INCREASED UROGENITAL SENSITIVITY AND FUNCTION RESULTING FROM NEONATAL MATERNAL SEPARATION IN MALE MICE Isabella M. Fuentes, Angela N. Pierce, Olivia C. Eller-Smith, Julie A. Christianson Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) shares m...
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Exercise promotes glucose clearance by increasing skeletal muscle GLUT4-mediated glucose uptake. Importantly, exercise upregulates muscle GLUT4 expression in an insulin-independent manner under conditions of insulin resistance, such as with type 2 diabetes. However, the insulin-independent mechanism responsible for rescued muscle GLUT4 expression is poorly understood. We used voluntary wheel ru...
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Voluntary wheel running can potentially be used to exacerbate the disease phenotype in dystrophin-deficient mdx mice. While it has been established that voluntary wheel running is highly variable between individuals, the key parameters of wheel running that impact the most on muscle pathology have not been examined in detail. We conducted a 2-week test of voluntary wheel running by mdx mice and...
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ژورنال
عنوان ژورنال: Molecular Therapy - Methods & Clinical Development
سال: 2021
ISSN: 2329-0501
DOI: 10.1016/j.omtm.2021.02.024